ArticleInfectious diseases & clinical microbiology2026
Diagnostic Performance of Combination Disk and CIM Tests for Carbapenemase Detection in Enterobacterales Compared with Real-Time Multiplex PCR.
Article in Infectious diseases & clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to evaluate the diagnostic performance of the combination disk method and carbapenem inactivation method (CIM) for detecting carbapenemase production in Enterobacterales isolates with reduced susceptibility or resistance to carbapenems, using real-time multiplex polymerase chain reaction (PCR) as the reference method. Materials and Methods: Enterobacterales isolates obtained from clinical samples between 2015 and 2016, which were at least minimally susceptible or resistant to at least one carbapenem, were included in the study. Phenotypic evaluation was performed using the KPC&MBL&OXA-48 combination disk kit (Liofilchem, Italy), which detects Results: A total of 111 Enterobacterales isolates were analyzed. The majority of isolates were Conclusion: The carbapenem inactivation method demonstrated high diagnostic accuracy for detecting carbapenemase production. The combination disk method, including temocillin resistance and ethylenediaminetetraacetic acid (EDTA)-based evaluation, showed strong performance in predicting OXA-48- and NDM-associated carbapenemases. However, in endemic regions, phenotypic results should ideally be confirmed by molecular methods.
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