ArticleHealth science reports2026
Effects of a Moisturizer and Emollient on the Stratum Corneum Assessed by Confocal Raman Spectroscopy in Patients With and Without Atopic Dermatitis: An Assessor-Blinded Prospective Cohort Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Atopic dermatitis (AD) is characterized by impaired skin barrier function and reduced moisturizing factors. Moisturizers and emollients restore the barrier through distinct mechanisms, but their longitudinal molecular effects on the stratum corneum (SC) are poorly characterized, particularly in barrier-deficient skin. We assessed the time-dependent effects of a cream-type moisturizer (CM) and petroleum jelly (PJ) on SC molecular composition in adults with and without AD using confocal Raman spectroscopy (CRS). Methods: In this assessor-blinded prospective cohort study (November 2019-February 2020), 12 adults without AD and 12 with AD applied 0.5 g each of CM and PJ to randomly assigned right or left forearms once daily for 28 (+ 7) days. SC water content, natural moisturizing factor (NMF), ceramide, cholesterol, and lactic acid were measured by CRS at 0, 14, and 28 days; transepidermal water loss (TEWL) and SC hydration were also assessed. Welch's Results: Twenty-three participants (non-AD, Conclusion: Moisturizers and emollients exerted distinct effects on SC components. Moisturizers were superior, increasing ceramide and lactic acid in the upper SC of patients with AD, and appear better suited for managing skin barrier dysfunction.
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