ReviewHealth science reports2026
The Effects of Fermentable Oligo-, Di-, and Monosaccharides and Polyols on Dyspeptic Symptoms: A Systematic Review and Meta-Analysis of Clinical Trials.
Review in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Conflicting evidence is available regarding the effects of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) on dyspeptic symptoms. Therefore, this systematic review and meta-analysis was performed to assess the effects of FODMAPs on dyspeptic symptoms. Methods: A systematic search up to October 2025 was performed through PubMed, ISI Web of Science, Scopus, Cochrane Library, and EMBASE. Randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSIs) examined the impact of the low-FODMAP diet (LFD) as the intervention group and the high-FODMAP diet (HFD) as the control diet on dyspeptic symptoms, including early satiety, pain, bloating, fullness, and nausea were included. The search strategy involved combining FODMAP-related terms with dyspeptic terms and symptoms. The mean severity of dyspeptic symptoms was pooled using a random-effects model and was reported as the weighted mean difference (WMD) and 95% confidence interval (CI). The certainty of the evidence was assessed with the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: A total of 12 studies (6 RCTs and 6 NRSIs) were eligible for inclusion in this meta-analysis. Compared with an HFD, an LFD significantly decreased the severity of bloating (WMD = -0.36, 95% CI: -0.58, -0.14; Conclusion: An LFD significantly reduced the severity of bloating and early satiety. However, these findings were substantially heterogeneous, and the certainty of the evidence was very low, which needs to be confirmed by further RCTs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.