Evidence map›Paper›PMID 42327372›Full record

ArticleCase reports in nephrology2026

Dual Aetiology of Diabetes Insipidus in Pregnancy: Vasopressinase-Mediated and Central Mechanisms.

Philani Ezekiel Mkhize, Pauli van Heerden, Tholakele Sabela, Mogamat Razeen Davids, Mogamat-Yazied Chothia

Abstract read
In one paragraph

Article in Case reports in nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Philani Ezekiel MkhizeDepartment of Medicine, Division of Nephrology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, sun.ac.za.ORCID https://orcid.org/0009-0008-9211-0122
Pauli van HeerdenDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, sun.ac.za.ORCID https://orcid.org/0000-0003-4877-0605
Tholakele SabelaDepartment of Medicine, Division of Nephrology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, sun.ac.za.ORCID https://orcid.org/0009-0009-6389-2660
Mogamat Razeen DavidsDepartment of Medicine, Division of Nephrology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, sun.ac.za.ORCID https://orcid.org/0000-0003-4900-0231
Mogamat-Yazied ChothiaDepartment of Medicine, Division of Nephrology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, sun.ac.za.ORCID https://orcid.org/0000-0002-9801-1300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes insipidus (DI) is a heterogeneous disorder characterised by polyuria and polydipsia due to impaired arginine vasopressin (AVP) secretion or action. We describe a 36-year-old pregnant woman who presented at 28 weeks' gestation with weakness, severe hypokalaemia from renal potassium wasting, hypernatraemia and polyuria with dilute urine. Vasopressinase-mediated DI was suspected; there was no response to AVP, but desmopressin (dDAVP) produced a rapid clinical improvement, confirming the diagnosis. However, postpartum recurrence of symptoms prompted further evaluation, with imaging suggestive of lymphocytic infundibuloneurohypophysitis, necessitating reinitiation of dDAVP. This case highlights the diagnostic complexity of DI in pregnancy and the need to remain vigilant for central causes, even when vasopressinase-mediated DI is initially suspected.

Indexed as

desmopressindiabetes insipidusgestationvasopressinase

Identifiers

PMID42327372
PMCPMC13280982

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.