ArticleBrain communications2026
When pain becomes self: limbic-default mode network hyperconnectivity predicts microvascular decompression failure in trigeminal neuralgia.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Microvascular decompression is the standard surgical intervention for classical trigeminal neuralgia attributed to NVC. However, up to 30% of patients experience poor outcomes despite technically successful surgery, suggesting non-peripheral mechanisms. This study investigates whether central neural reorganization-manifested as altered cortico-subcortical connectivity and white matter microstructure-underlies poor surgical outcomes in patients with 'incidental' low-pressure vascular contact. In this prospective nested case-control study, we enrolled 60 patients with medication-refractory classical trigeminal neuralgia who underwent microvascular decompression and 30 matched healthy controls. Based on the 3-month surgical outcome, patients were retrospectively stratified into effective and ineffective groups. All participants underwent preoperative resting-state functional MRI and diffusion tensor imaging. Whole-brain functional connectivity between 100 cortical (Schaefer atlas) and 16 subcortical (Tian atlas) regions was analysed. Connections were ranked by between-group effect size (Cohen's
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