Evidence map›Paper›PMID 42327334›Full record

ArticlebioRxiv : the preprint server for biology2026

Multiplex engineering of rhesus macaque NK cells enhances homing to sites of HIV replication in B cell follicles.

Liliana K Thron, Mary S Pampusch, Jae-Woong Chang, Joshua Kreuger, Maxwell E Cantor, Matthew J Johnson, Dawn M Dudley, Branden S Moriarity, Pamela J Skinner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liliana K ThronDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0009-3867-6448
Mary S PampuschDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.
Jae-Woong ChangDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Joshua KreugerDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID 0009-0002-7658-149X
Maxwell E CantorDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.
Matthew J JohnsonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Dawn M DudleyWisconsin National Primate Research Center, Madison, WI, USA.
Branden S MoriarityDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-3031-3767
Pamela J SkinnerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-3388-1687

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Activated NK CAR Cells to Cure HIVR01AI161017 · NIAID · UNIVERSITY OF MINNESOTA · PI MORIARITY, BRANDEN S, SKINNER, PAMELA J · 2021 to 2025
$3.8M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
EXTRAMURAL REGIONAL FACILITIES CONSTRUCTIONC06RR015459 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2000 to 2000
$1.9M
NCRR NIH HHS C06 RR015459NCRR NIH HHS C06 RR020141NIAID NIH HHS R01 AI161017NIH HHS P51 OD011106
6 · The paper itself

Abstract

One barrier to developing an HIV-1 cure is viral reservoirs persisting within B cell follicles of lymphatic tissues, partly due to failure of HIV-specific cytotoxic cells to express the follicular-homing receptor CXCR5. Our group explores CAR cell therapies which also express CXCR5 as a potential cure strategy for HIV. Although previous studies have mostly explored CAR T cell therapies, CAR NK cells may be an attractive alternative as they can be used in allogeneic settings and are naturally cytotoxic towards HIV-infected cells. Here, we developed a novel and innovative multiplex engineering method for rhesus macaque NK cells to create virus-specific CAR NK cells multiplexed (MP) with CAR/CXCR5/IL-15/PD-1 KO/transient-CCR7. We first evaluated MP NK cells

Indexed as

base editorCAR therapyHIVmultiplex engineeringNK cellsRhesus MacaquesSIVtrogocytosis

Identifiers

PMID42327334
PMCPMC13278085

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.