Evidence map›Paper›PMID 42327278›Full record

ArticlebioRxiv : the preprint server for biology2026

Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.

Emily N Bitsko, David R Joyner, Jeffrey R Maslanka, Kyra Woloszczuk, Arden O Edgerton, Matthew R Bell, Christian Sell, Mohamad-Gabriel Alameh, Joris Beld, Elias K Haddad and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily N BitskoDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0009-0007-6039-8857
David R JoynerDrexel University College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA.
Jeffrey R MaslankaImmunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0002-6982-5946
Kyra WoloszczukDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0009-0001-1196-3203
Arden O EdgertonDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0009-0004-9913-3432
Matthew R BellDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0000-0001-7246-4021
Christian SellUniversity of Pennsylvania Perelman School of Medicine, Department of Microbiology, Philadelphia, PA.ORCID 0000-0002-4332-1141
Mohamad-Gabriel AlamehDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5672-6930
Joris BeldDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0000-0001-7070-663X
Elias K HaddadDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0000-0002-4537-8301
Michael C AbtImmunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0002-7351-2061
Michele A KutzlerDrexel University College of Medicine, Department of Microbiology and Immunology, Philadelphia, PA.ORCID 0000-0001-5692-5617

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DREW WEISSMAN · 2023 to 2026
$7.6M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Novel longevity enhancing pathways regulated by mTORR01AG071815 · NIA · DREXEL UNIVERSITY · PI CHRISTIAN SELL · 2022 to 2026
$2.5M
Investigating Immune-Microbiome interactions during treatment of Clostridioides difficile with fecal microbiome transplantationR01AI158830 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ABT, MICHAEL C. · 2021 to 2025
$2.4M
Novel longevity enhancing pathways regulated by mTORR56AG071815 · NIA · DREXEL UNIVERSITY · PI SELL, CHRISTIAN · 2021 to 2021
$310k
NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS R01 AI158830NIAID NIH HHS U19 AI174998NIA NIH HHS R01 AG071815NIA NIH HHS R56 AG071815NIDA NIH HHS 75N95020D00005NIH HHS 75N93023D00005NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Older adults experience disproportionate morbidity and mortality from

Identifiers

PMID42327278
PMCPMC13278030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.