Evidence map›Paper›PMID 42327261›Full record

ArticlebioRxiv : the preprint server for biology2026

Bo Zhou, Satabdi Mohanty, Paris Riggle, Takao Tsukahara, Grace Lin, Louis T Dang, Michael A Sutton, Shigeki Iwase

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo ZhouHuman Genetics Department, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Satabdi MohantyHuman Genetics Department, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-9820-0259
Paris RiggleHuman Genetics Department, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0009-0006-9253-0878
Takao TsukaharaDivision of Biochemistry, Meikai University, School of Dentistry, Sakado, Saitama, 350-0283, Japan.ORCID 0009-0002-3020-8091
Grace LinPediatrics Department, Division of Pediatric Neurology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Louis T DangPediatrics Department, Division of Pediatric Neurology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-4853-4952
Michael A SuttonMolecular & Integrative Physiology Department, Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Shigeki IwaseHuman Genetics Department, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-2280-7422

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Dissecting Histone H3K4 Methylation Enzymes in NeuroplasticityR01MH133632 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shigeki Iwase, Michael Mark Alexander Sutton · 2024 to 2026
$2.0M
Circadian and homeostatic regulation of sleep in a diurnal model of Smith-Magenis SyndromeR01NS141983 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brendon O Watson · 2025 to 2026
$1.2M
Diurnal Experimental Models to Investigate Neural Mechanisms of Sleep Disturbance in Smith-Magenis SyndromeR21NS125449 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IWASE, SHIGEKI, YAN, LILY · 2021 to 2021
$444k
Developing a Diurnal Rodent Model for Smith-Magenis SyndromeR03NS137487 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IWASE, SHIGEKI, YAN, LILY · 2024 to 2024
$170k
NCI NIH HHS P30 CA046592NIMH NIH HHS R01 MH133632NINDS NIH HHS R01 NS141983NINDS NIH HHS R03 NS137487NINDS NIH HHS R21 NS125449
6 · The paper itself

Abstract

Human brain development proceeds on an unusually long timeline relative to other species, a feature that is thought to foster advanced cognitive abilities. The Retinoic Acid Induced 1 (RAI1) gene encodes a nucleosome-binding protein, and its haploinsufficiency is responsible for Smith-Magenis Syndrome (SMS), a neurodevelopmental disorder characterized by cognitive impairment with autistic features. However, the role of

Identifiers

PMID42327261
PMCPMC13278167

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.