Evidence map›Paper›PMID 42327248›Full record

ArticlebioRxiv : the preprint server for biology2026

Rosindol: A fluorogen for the quantitative measurement of reactive oxygen species in living cells.

Andrew Monnone, Molly Nicknish, Juan Jaramillo Montezco, Christine Sanganoo, Nalin Aggarwal, Arista Luong, Scott Schaus, Mark Grinstaff

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew MonnoneDepartment of Chemistry, Boston University, Boston MA, USA.ORCID 0000-0002-5636-4984
Molly NicknishDepartment of Chemistry, Boston University, Boston MA, USA.ORCID 0009-0003-9888-6259
Juan Jaramillo MontezcoDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.ORCID 0000-0003-2462-2018
Christine SanganooDepartment of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-9656-3056
Nalin AggarwalDepartment of Chemistry, Boston University, Boston MA, USA.
Arista LuongDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Scott SchausDepartment of Chemistry, Boston University, Boston MA, USA.ORCID 0000-0002-5877-6587
Mark GrinstaffDepartment of Chemistry, Boston University, Boston MA, USA.ORCID 0000-0002-5453-3668

Funding

TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGYT32GM008764 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WHITE, JOHN A. · 2001 to 2021
$5.9M
Synthetic Biology and Biotechnology (SB2) Predoctoral Training ProgramT32GM130546 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S, KHALIL, AHMAD SAMIR · 2019 to 2023
$1.0M
NIGMS NIH HHS T32 GM008764NIGMS NIH HHS T32 GM130546
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are key mediators of disease, yet accurate characterization in living systems remains challenging because current probes lack oxidation specificity and produce nonlinear, pH-dependent signals. Here we introduce Rosindol, a novel thioacetal-based fluorogenic probe that overcomes these limitations. Rosindol undergoes an

Identifiers

PMID42327248
PMCPMC13277976

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.