ArticlebioRxiv : the preprint server for biology2026
Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs.
Jiseok Lee, Hyunggyu Min, Cristine Casingal, Austin T Ledford, Hannah Lee, Won Ma, Yangzhenyu Gao, Hanqian Mao, Eric S McCoy, Lei Xing and 8 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Hyunggyu MinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Austin T LedfordNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Hannah LeeNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Yangzhenyu GaoDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0009-0009-5267-0122 Hanqian MaoNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Eric S McCoyNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Cindy FangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0001-7164-5461 Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD.ORCID 0000-0002-5237-0789 Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD.ORCID 0000-0003-0031-8468 Stephanie C HicksDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0002-7858-0231 Funding
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5MSystematic in vivo characterization of disease-associated regulatory variantsUM1HG012003 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Isaiah Love, KAREN L. MOHLKE · 2021 to 2026
$9.9MPostdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5MDEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITYR35NS116859 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVA S ANTON · 2020 to 2026
$4.1MPrimary Cilia: A Novel Signaling Gateway To Neural Circuit ModulationR01MH132710 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, LICHTMAN, JEFF W · 2022 to 2024
$3.3MPrimary Cilia: A Novel Signaling Gateway To Neural Circuit ModulationRF1MH132710 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S, LICHTMAN, JEFF W · 2025 to 2025
$2.2MDiscovery and validation of genetic variation impacting the gene regulatory landscape during human cortical developmentR01MH122509 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEIN, JASON LOUIS, WON, HYEJUNG · 2023 to 2025
$1.6MNHGRI NIH HHS UM1 HG012003NICHD NIH HHS T32 HD040127NIDDK NIH HHS P30 DK034987NIMH NIH HHS R01 MH122509NIMH NIH HHS R01 MH132710NIMH NIH HHS RF1 MH132710NINDS NIH HHS R35 NS116859
6 · The paper itselfAbstract
Schizophrenia (SCZ) is a common psychiatric disorder characterized by psychosis, emotional withdrawal, and cognitive deficits. Most SCZ risk variants reside in non-coding regions of the genome and are thought to influence disease risk by modulating gene regulation. However, the target genes, biological pathways, and cell types through which these variants exert their effects remain poorly understood. To address this gap, we employed
Identifiers
PMID42327190
PMCPMC13278005
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