Evidence map›Paper›PMID 42327178›Full record

ArticlebioRxiv : the preprint server for biology2026

A modular neural circuit for computing the motion of objects.

Ethan Trepka, Catherine Yue, Ruobing Xia, Shude Zhu, Sharif Saleki, Danielle Abreu Lopes, Stephen Niño Cital, Tirin Moore

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ethan TrepkaNeuroscience Interdepartmental Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3002-800X
Catherine YueHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6233-0254
Ruobing XiaDepartment of Neurobiology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1460-5882
Shude ZhuHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8674-9607
Sharif SalekiHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0275-5277
Danielle Abreu LopesHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Stephen Niño CitalHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0009-0002-5985-6113
Tirin MooreHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3345-2930

Funding

Interaction of Visual and Oculomotor Signals in CortexR01EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2004 to 2024
$7.3M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionRF1NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, SHENOY, KRISHNA V · 2020 to 2022
$1.8M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionR01NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, WALLIS, JONI D · 2023 to 2024
$1.0M
Interaction of Visual and Oculomotor Signals in CortexR56EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2009 to 2009
$398k
NEI NIH HHS R01 EY014924NEI NIH HHS R56 EY014924NINDS NIH HHS R01 NS116623NINDS NIH HHS RF1 NS116623
6 · The paper itself

Abstract

Computing the direction of a moving object requires integrating motion signals from its component edges into coherent patterns. The representation of pattern motion in visual cortex has been extensively studied, yet its underlying neural circuitry remains unknown. Using high-density recordings in macaque area MT, we show that selectivity to pattern motion emerges from a functionally and anatomically distinct cortical circuit. We demonstrate that neurons specialized for encoding component and pattern motion comprise distinct cell types arranged in a hierarchical circuit in which pattern neurons integrate inputs from a range of component neurons. Furthermore, we show that component and pattern neurons are spatially segregated into modules arranged systematically across cortical columns encoding direction of motion. This architecture and circuit align with a classic solution to the problem of computing the motion of objects.

Indexed as

Motion ProcessingNeuronal DynamicsVisual Cortex

Identifiers

PMID42327178
PMCPMC13278120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.