Evidence map›Paper›PMID 42327157›Full record

ArticlebioRxiv : the preprint server for biology2026

Regulatory landscape of widespread stop codon readthrough in

Nadezhda Makarova, Daniel Martín de la Fuente, Mihajlo Stašuk, Ivet Ortiga Martínez, Jonas Pöhls, Irwin Jungreis, Manolis Kellis, Federica Battistini, Diego Garrido Martín, Alain Lescure and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nadezhda MakarovaDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.ORCID 0000-0001-6927-5748
Daniel Martín de la FuenteDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.
Mihajlo StašukDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.ORCID 0009-0004-5563-354X
Ivet Ortiga MartínezDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.
Jonas PöhlsMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-6137-2794
Irwin JungreisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology; and Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3197-5367
Manolis KellisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology; and Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
Federica BattistiniInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology; and Department of Biochemistry and Biomedicine, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-7544-0938
Diego Garrido MartínDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.ORCID 0000-0002-4131-4458
Alain LescureUniversity of Strasbourg, CNRS, Architecture and Reactivity of RNA, Strasbourg, France.ORCID 0000-0002-0791-6818
Agnes Toth-PetroczyMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-0333-604X
Marco MariottiDepartment of Genetics, Microbiology and Statistics; and Institut de Biomedicina de la Universitat de Barcelona; Universitat de Barcelona; Barcelona, Spain.ORCID 0000-0002-7411-4161

Funding

GENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1M
NHGRI NIH HHS U24 HG007234
6 · The paper itself

Abstract

In stop codon readthrough (SCR), ribosomes continue to translate past the stop. While programmed SCR is rare in mammals, it appears remarkably widespread in insects, yet its regulation and biological significance remain poorly understood. Here, we systematically characterize SCR in

Indexed as

Drosophilafunctional genomicsinsectsribosome profilingstop codon readthrough

Identifiers

PMID42327157
PMCPMC13278127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.