Evidence map›Paper›PMID 42327156›Full record

ArticlebioRxiv : the preprint server for biology2026

Human interferon stimulated genes target ancient features of animal and bacterial viral replication.

Samantha G Fernandez, Jill E Hutchinson, Joel M J Tan, Sonomi Yamaguchi, Anne A Roffler, Aaron G Schmidt, Philip J Kranzusch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha G FernandezDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0005-3303-9619
Jill E HutchinsonDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Joel M J TanDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Sonomi YamaguchiDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Anne A RofflerRagon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA.
Aaron G SchmidtDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3627-2553
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Frank V Murphy · 2018 to 2026
$34.2M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527
6 · The paper itself

Abstract

Animal and bacterial cells defend against viral infection by rapidly activating antiviral restriction factors. In human cells, antiviral immunity is initiated by interferon signaling that results in expression of hundreds of interferon-stimulated genes (ISGs)

Identifiers

PMID42327156
PMCPMC13277981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.