Evidence map›Paper›PMID 42327154›Full record

ArticlebioRxiv : the preprint server for biology2026

Programmable pathway profiles reveal signaling principles of TGF-β superfamily receptors.

Bo Gu, James M Linton, Brice Graham Hendrickson, Hengyu Li, Ron Hadas, Gal Manella, Jan Gregrowicz, Bryan Anggito, Rong Lu, Michael B Elowitz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bo GuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-6711-4139
James M LintonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Brice Graham HendricksonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Hengyu LiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Ron HadasDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Gal ManellaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Jan GregrowiczDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Bryan AnggitoDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Rong LuDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Michael B ElowitzDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-1221-0967

Funding

A spatial view of hematopoietic regeneration dynamics in the bone marrowR01DK143671 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MICHAEL B ELOWITZ, Rong Lu · 2024 to 2026
$8.1M
Investigating the heterogeneity and coordination of hematopoietic stem cells (Diversity Supplement)R35HL150826 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Rong Lu · 2020 to 2026
$6.8M
Dynamics of chromosome organization and chromatin states in single cellsU01DK127420 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAI, LONG, ELOWITZ, MICHAEL B · 2020 to 2024
$5.7M
Cell targeting with synthetic sense-and-respond protease circuitsR01EB030015 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ELOWITZ, MICHAEL B · 2020 to 2023
$2.3M
NHLBI NIH HHS R35 HL150826NIBIB NIH HHS R01 EB030015NIDDK NIH HHS R01 DK143671NIDDK NIH HHS U01 DK127420
6 · The paper itself

Abstract

The Transforming Growth Factor beta (TGF-β) superfamily, like other biological pathways, relies on families of co-expressed, partially redundant protein components, such as receptor subunits. The inability to systematically modulate multi-gene component expression profiles has made it difficult to understand how components and sets of components collectively process information. To overcome this, we developed

Identifiers

PMID42327154
PMCPMC13278012

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.