ArticlebioRxiv : the preprint server for biology2026
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Silvia CasadeiBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2619-5662
Matthew W SnyderBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7433-4343
Ivan WooBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0003-0945-8851
Nahum SmithBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0007-5494-7477
Sabrina BestBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0008-6352-0106
Riddhiman K GargeBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6774-0172
Leslie Rodriguez-SalasBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0008-0602-8035
Cameron WenmanBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0001-0819-0326
Obsa SeidBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0008-4348-1082
Airi HosokaiBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0008-5802-7130
Alicia XuBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0001-9766-3622
Malvika TejuraDepartment of Genome Sciences, School of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5356-1977
Pankhuri GuptaBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0002-5802-1296
Sarah HeidlBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0000-7692-9391
Lara MuffleyBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3035-3339
Jane RanchalisDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0004-1654-4114
Ross StewartKhoury College of Computer Sciences, Northeastern University, Boston, MA, USA.ORCID 0009-0006-4240-9308
Noah J GoffDepartment of Biochemistry and Biophysics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-4925-4146
Shelby L HemkerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-9135-7042
John BaierlDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0004-4948-6766
Ed M DicksDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0617-0401
Paul PharoahSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, West Hollywood, CA, USA.ORCID 0000-0001-8494-732X
Lene BjornkjaerDepartment of Clinical Genetics, Vejle Hospital, Lillebælt Hospital, Vejle, Denmark.
Karina RoenlundDepartment of Clinical Genetics, Vejle Hospital, Lillebælt Hospital, Vejle, Denmark.
Jacob O KitzmanDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-6145-882X
Kara A BernsteinDepartment of Biochemistry and Biophysics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-2247-6459
Andrew B StergachisDepartment of Genome Sciences, School of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1299-3674
Predrag RadivojacKhoury College of Computer Sciences, Northeastern University, Boston, MA, USA.ORCID 0000-0002-6769-0793
Douglas M FowlerBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7614-1713
Lea M StaritaBrotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2870-5099
Funding
Technology to understand genetic variant effects in contextRM1HG010461 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Bruce Colston Trapnell · 2019 to 2026
$18.9MUniversity of Washington Mendelian Genomics Research Center (UW-MGRC)U01HG011744 · NHGRI · UNIVERSITY OF WASHINGTON · PI MICHAEL Joseph BAMSHAD, Evan Eichler · 2021 to 2026
$15.8MThe Center for Actionable Variant Analysis; measuring variant function at scaleUM1HG011969 · NHGRI · UNIVERSITY OF WASHINGTON · PI Douglas M Fowler, Lea Starita · 2021 to 2026
$9.9MTranslational Research Training Program in Environmental Health SciencesT32ES019851 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Kara A Bernstein, Trevor M Penning · 2012 to 2026
$6.0MSupporting IGVF by modeling genetics, function, and phenotype with machine learningU01HG012022 · NHGRI · NORTHEASTERN UNIVERSITY · PI Predrag Radivojac · 2021 to 2026
$3.4MAdvancing the implementation of variant-level functional data into clinical databases and clinical practiceR01HG013025 · NHGRI · UNIVERSITY OF WASHINGTON · PI Lea Starita, Andrew Ben Stergachis · 2023 to 2026
$3.1MExpanding the Reach of Massively Parallel Variant Effect ScreensR35GM153286 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacob Otto Kitzman · 2024 to 2026
$1.5MNHGRI NIH HHS R01 HG013025NHGRI NIH HHS RM1 HG010461NHGRI NIH HHS U01 HG011744NHGRI NIH HHS U01 HG012022NHGRI NIH HHS UM1 HG011969NIEHS NIH HHS T32 ES019851NIGMS NIH HHS R35 GM153286
Abstract
Germline pathogenic variants in
Indexed as
Hereditary breast and ovarian cancerHomologous recombinationRAD51DSaturation genome editingSplice-altering variationVariant effect mapsXRCC2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.