Evidence map›Paper›PMID 42327143›Full record

ArticlebioRxiv : the preprint server for biology2026

A U1-U3 snRNA-snoRNA interaction couples SF3B1 mutation to chromatin-state rewiring and genome instability.

Peng Xia, Han Li, Yiyi Ji, Cheng-Wei Ju, Yiqian Pan, Jing Mo, Xuanhao Zhu, Lijie Zhao, Ruitu Lv, Erica Niewold and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Peng XiaDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-6046-3790
Han LiDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Yiyi JiDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Cheng-Wei JuDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Yiqian PanDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Jing MoDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Xuanhao ZhuDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Lijie ZhaoDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Ruitu LvDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4597-1604
Erica NiewoldDepartment of Systems Biology, Beckman Research Institute of the City of Hope, Monrovia, CA, USA.
Mike FernandezIrell Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Yuxi AiMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
Jiangbo WeiDepartment of Chemistry, National University of Singapore, Singapore 119077, Singapore.
Robert K BradleyComputational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-8046-1063
Lili WangHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5028-2868
Omar Abdel-WahabMolecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer, New York, NY 10065, USA.
Bei LiuDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in spliceosome factors such as SF3B1 are recurrent across human diseases, including myelodysplastic syndromes and leukemia

Identifiers

PMID42327143
PMCPMC13277980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.