Evidence map›Paper›PMID 42327141›Full record

ArticlebioRxiv : the preprint server for biology2026

Multimodal classification of neurons in the lateral septum.

Christopher M Reid, Yuqi Ren, Rhiana Simon, Yajun Xie, Miguel Turrero Garcίa, Diana Tran, Steve Vu, Jonathan Liu, Manal A Adam, Sarah M Hanson and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher M ReidDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Yuqi RenDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Rhiana SimonDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Yajun XieDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.ORCID 0000-0003-2988-2708
Miguel Turrero GarcίaDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.ORCID 0000-0002-7294-169X
Diana TranDepartment of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.
Steve VuDepartment of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.
Jonathan LiuChan Zuckerberg Biohub San Francisco, San Francisco, CA, 94158, USA.
Manal A AdamDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.ORCID 0000-0002-1590-063X
Sarah M HansonDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.
Angela O PiscoChan Zuckerberg Biohub San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0003-0142-2355
Corey C HarwellDepartment of Neurology, University of California, San Francisco, CA, 94143, USA.ORCID 0000-0002-8043-5869

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lateral septum (LS) is a ventral forebrain nucleus that modulates complex social and affective behaviors. These behaviors emerge from heterogeneous neuronal populations whose molecular identity and developmental origins remain poorly defined. We profiled the transcriptional identity of mature LS neurons derived from two progenitor lineages distinguished by their embryonic origin and Nkx2.1 expression history, identifying 22 molecularly distinct subtypes. Nkx2.1-lineage neurons are enriched for select cell adhesion and communication molecules; however, subtypes from distinct developmental origins can converge onto similar molecular profiles when residing within the same LS subregion. The graded expression of genes related to synaptic signaling is a primary axis defining the taxonomy of LS neurons. Using transcriptional markers, we labeled non-overlapping neuronal populations and characterized their connectivity, morphology, and electrophysiology. Together, these findings define the extent of LS neuronal diversity and provide a framework for understanding how complex behaviors are regulated by the LS.

Identifiers

PMID42327141
PMCPMC13277926

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.