Evidence map›Paper›PMID 42327131›Full record

ArticlebioRxiv : the preprint server for biology2026

Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages.

Alan Y Baez Vazquez, Daisy A Hoagland, Alexander O Mann, Yunkang Lin, Susanna M Dang, Max Hauptschein, Louison Thorens, Shahinoor Begum, Martha A Castro, Patricia Rodríguez-Morales and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alan Y Baez VazquezDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5768-1271
Daisy A HoaglandDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6781-3079
Alexander O MannDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5927-1396
Yunkang LinDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9182-8158
Susanna M DangDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5768-0535
Max HauptscheinDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8478-568X
Louison ThorensInstitute for Mechanobiology, Department of Bioengineering, Northeastern University, Boston, MA, USA.ORCID 0000-0001-8913-0327
Shahinoor BegumDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0009-0003-3472-4605
Martha A CastroDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1964-1321
Patricia Rodríguez-MoralesDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2646-4482
Alicia LaiDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Irving BarreraBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Dawei SunDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-1551-4349
Andrea ShehajDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Fei ChenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2308-3649
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Carla F KimDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2366-9538
Ruth A FranklinDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6563-6187

Funding

NRSA Training CoreTL1TR002543 · NCATS · HARVARD MEDICAL SCHOOL · PI MICHEL, THOMAS · 2018 to 2022
$3.4M
Macrophage-mediated regulation of inflammation and tissue repairR35GM150816 · NIGMS · HARVARD MEDICAL SCHOOL · PI Ruth A Franklin · 2023 to 2026
$1.9M
Macrophage-Mediated Lung Repair Programs Following InjuryF31HL172650 · NHLBI · HARVARD UNIVERSITY · PI Alan Baez Vazquez · 2024 to 2026
$113k
NCATS NIH HHS TL1 TR002543NHLBI NIH HHS F31 HL172650NIGMS NIH HHS R35 GM150816
6 · The paper itself

Abstract

Lung repair in response to viral infection requires integrated communication between epithelial and immune compartments, yet the impact of antiviral mediators on epithelial regenerative capacity remains poorly defined. Here, we demonstrate that type I interferon (IFN-I) signaling primes the lung for alveolar renewal following viral challenge. IFN-I contributes to the induction of an interferon-stimulated gene-high (ISG)

Indexed as

EpitheliumInnate immunityMacrophagesTissue repairViral infection

Identifiers

PMID42327131
PMCPMC13277943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.