Evidence map›Paper›PMID 42327112›Full record

ArticlebioRxiv : the preprint server for biology2026

Coordinated immune-epithelial dynamics in the nasal epithelium protect against respiratory virus infection.

Yao Yu Yeo, Hsin-Yi Chen, Bokai Zhu, Yang Wang, Ivan T Lee, Tsuguhisa Nakayama, Yuchen Wang, Huaying Qiu, Kate B Juergens, Sei Chung and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yao Yu YeoCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Hsin-Yi ChenDepartment of Microbiology, UT Southwestern Medical Center, Dallas, TX, United States.
Bokai ZhuDepartment of Pathology, Stanford University, Stanford, CA, United States.
Yang WangCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Ivan T LeeDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Tsuguhisa NakayamaDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Yuchen WangCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Huaying QiuCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Kate B JuergensProgram in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA, United States.
Sei ChungDepartment of Otolaryngology-Head and Neck Surgery, UT Southwestern Medical Center, Dallas TX, USA.
Carol H YanDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, United States.
Clara S KummererCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Hendrik A MichelCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Andrew Z MaCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Wenrui WuCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Garry P NolanDepartment of Pathology, Stanford University, Stanford, CA, United States.
David R McIlwainDepartment of Microbiology and Immunology, University of Nevada Reno School of Medicine, Reno, NV, United States.
Alexandar TzankovInstitute of Pathology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-1100-3819
Matthias S MatterInstitute of Pathology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-2005-5266
Chien-Ting WuDepartment of Microbiology, UT Southwestern Medical Center, Dallas, TX, United States.
Sizun JiangCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-6149-3142

Funding

Spatial-Temporal Dissection of Stratified Host Tissue Responses to Severe acute respiratory syndrome-related coronaviruses in situ to Understand Intra-host PathogenesisDP2AI171139 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Sizun Jiang · 2022 to 2026
$2.3M
Cilia-mediated mechanisms of viral entry into nasal mucosaR01AI184984 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Chien-Ting Wu · 2024 to 2026
$1.5M
Bill & Melinda Gates Foundation INV-002704NIAID NIH HHS DP2 AI171139NIAID NIH HHS R01 AI184984
6 · The paper itself

Abstract

Epithelial remodeling is a hallmark of host antiviral responses that strengthen barrier defenses against infection. Our current understanding of viral pathophysiology within the nasal epithelium, the initial site of most respiratory viral infections, remains incomplete due to limited understanding of the native tissue architecture and protective epithelial remodeling during immune events. Leveraging coronavirus disease 2019 (COVID-19) as a model, we applied spatial multi-omics on nasal cross-sectional tissues to characterize the immune-epithelial landscape during infection, identifying a coordinated increase in goblet cells and suppressive macrophages associated with elevated IL13 in the immune compartment. Our results further reveal that goblet cell and suppressive macrophage enrichment are spatially linked in proximity to IL13-expressing CD4 T cells, consistent with IL13-driven remodeling

Indexed as

Air-Liquid InterfaceCOVID-19Immune-Epithelial RemodelingNasal EpitheliumRespiratory VirusSpatial ProteomicsSpatial Transcriptomics

Identifiers

PMID42327112
PMCPMC13278067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.