Evidence map›Paper›PMID 42327110›Full record

ArticlebioRxiv : the preprint server for biology2026

Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state in

Saba N Baskoylu, Amit Kundra, Sarah Pugliese, Jungsoo Kim, Kamal Maher, Alex Hiser, Frank Meng, Cassi Estrem, Di Kang, Eric Bueno and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saba N BaskoyluHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Amit KundraHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sarah PuglieseHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jungsoo KimHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kamal MaherHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alex HiserHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Frank MengHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cassi EstremHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Di KangHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eric BuenoHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Steven W FlavellHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegansR01DC020484 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Steven Willem Flavell · 2023 to 2026
$1.5M
Dissecting the functional organization of the serotonergic system in C. elegansR01GM135413 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FLAVELL, STEVEN WILLEM · 2020 to 2023
$1.2M
NIDCD NIH HHS R01 DC020484NIGMS NIH HHS R01 GM135413
6 · The paper itself

Abstract

Transient sensory stimuli can trigger long-lasting changes in behavior and cognition. For example, repeated aversive experiences can lead to persistent changes in arousal and mood. Specialized integrator circuits can store information about recent experiences, but how they are embedded within the architecture of the brain to control internal brain states remains poorly understood. We find that

Identifiers

PMID42327110
PMCPMC13277833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.