Evidence map›Paper›PMID 42327100›Full record

ArticlebioRxiv : the preprint server for biology2026

Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice.

Xinyue Lu, Gabriela A Ferraz, Shivani Sivakumar, Hanan Tlais, Hamood Rehman, Binayok Sharma, Shikha Adhikari, Sophie Lies, Tingting Ju, Natasha Jaiswal and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinyue LuDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.ORCID 0009-0004-9011-8711
Gabriela A FerrazDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.ORCID 0009-0006-0752-4829
Shivani SivakumarDepartment of Health Sciences, College of Health and Human Sciences, Purdue University.
Hanan TlaisDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.ORCID 0009-0000-5567-3841
Hamood RehmanDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.ORCID 0009-0004-8957-8999
Binayok SharmaDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-7710-8050
Shikha AdhikariDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.
Sophie LiesDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.
Tingting JuDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.
Natasha JaiswalCenter for Aging and the Life Course (CALC), Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-4666-5430
Vandré C FigueiredoDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.ORCID 0000-0002-3012-7905
James F MarkworthDepartment of Animal Sciences, College of Agriculture, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-5348-1464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a gradual and progressive decline in skeletal muscle mass and strength known as sarcopenia, which has been attributed to chronic low-grade inflammation. Dietary long-chain polyunsaturated fatty acids (LC-PUFAs), including omega-6 arachidonic acid (ARA) and omega-3 docosahexaenoic acid (DHA), are precursors to bioactive lipid mediators that regulate the initiation, propagation, and active resolution of inflammation. While traditionally considered a pro-inflammatory and catabolic factor, the ARA-derived eicosanoid prostaglandin E

Identifiers

PMID42327100
PMCPMC13278036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.