Evidence map›Paper›PMID 42327095›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of connexin 43 in cartilage causes mitochondrial dysfunction and accelerates post-traumatic osteoarthritis progression.

Kristyna Hargitaiova, Rebecca M Irwin, Khizar Hayat, James Pham, Claire Ma, Alexandria M Davis, Miguel Otero, Michelle L Delco

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristyna HargitaiovaCornell University, Department of Clinical Sciences, Ithaca, NY.ORCID 0009-0007-3020-7319
Rebecca M IrwinCornell University, Department of Clinical Sciences, Ithaca, NY.ORCID 0000-0001-6549-9912
Khizar HayatCornell University, Department of Clinical Sciences, Ithaca, NY.ORCID 0000-0002-0950-9351
James PhamCornell University, Department of Clinical Sciences, Ithaca, NY.
Claire MaCornell University, Department of Clinical Sciences, Ithaca, NY.
Alexandria M DavisCornell University, Department of Clinical Sciences, Ithaca, NY.
Miguel OteroHospital for Special Surgery and Weill Cornell Medical College, New York City, NY.ORCID 0000-0002-4945-2994
Michelle L DelcoCornell University, Department of Clinical Sciences, Ithaca, NY.ORCID 0000-0003-0973-2075

Funding

Mitochondrial dysfunction as a link between cartilage injury and osteoarthritisK08AR068470 · NIAMS · CORNELL UNIVERSITY · PI DELCO, MICHELLE LEE · 2016 to 2021
$724k
The role of mitochondrial Damage Associated Molecular Patterns (mDAMPs) in posttraumatic osteoarthritis.R03AR075929 · NIAMS · CORNELL UNIVERSITY · PI DELCO, MICHELLE LEE · 2019 to 2020
$157k
NIAMS NIH HHS K08 AR068470NIAMS NIH HHS R03 AR075929
6 · The paper itself

Abstract

Osteoarthritis (OA) is a major cause of chronic pain and disability worldwide, characterized by progressive degeneration of cartilage and subchondral bone. Post-traumatic OA (PTOA) develops in as many as 25-50% of individuals following major joint injury, making it a leading cause of OA in younger and otherwise healthy populations.

Indexed as

Connexin 43crosstalkmitochondrial bioenergeticsosteochondral communicationpost-traumatic osteoarthritis

Identifiers

PMID42327095
PMCPMC13278044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.