Evidence map›Paper›PMID 42327085›Full record

ArticlebioRxiv : the preprint server for biology2026

Deciphering AMP deaminase-2 structure, activators and regulators underpinning cellular function in human fructose and nucleotide metabolism.

Ashley M Rebelo, Nemanja Vuksanovic, Lanlan Han, Dean R Tolan, Karen N Allen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashley M RebeloDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston MA 02215.ORCID 0000-0001-6691-6124
Nemanja VuksanovicDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston MA 02215.ORCID 0000-0003-2883-6312
Lanlan HanDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston MA 02215.ORCID 0009-0007-8050-1882
Dean R TolanDepartment of Biology, Boston University, 5 Cummington Mall, Boston MA 02215.ORCID 0000-0002-0598-7241
Karen N AllenDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston MA 02215.ORCID 0000-0001-7296-0551

Funding

Fructokinase Inhibitors for the Treatment of Alcohol Use DisorderU01AA027997 · NIAAA · COLORADO RESEARCH PARTNERS, LLC · PI JOHNSON, RICHARD JOSEPH · 2019 to 2023
$6.1M
NIAAA NIH HHS U01 AA027997
6 · The paper itself

Abstract

AMP deaminase (AMPD) plays an integral role in fructose metabolism

Indexed as

allosteric siteenzyme regulationhereditary fructose intolerancepurine metabolismuric acid metabolism

Identifiers

PMID42327085
PMCPMC13277832

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.