Evidence map›Paper›PMID 42327028›Full record

ArticlebioRxiv : the preprint server for biology2026

TRPM4 Couples Mechanical Force to Myogenic Constriction Throughout the Resistance Vasculature.

Wanchun Zhu, Alfredo Sanchez-Solano, Boris Lavanderos, Shiyue Pan, Yumei Feng Earley, Scott Earley

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanchun ZhuDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.ORCID 0000-0002-0313-2119
Alfredo Sanchez-SolanoDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.
Boris LavanderosDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.ORCID 0000-0002-6827-7095
Shiyue PanDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.
Yumei Feng EarleyDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.
Scott EarleyDepartment of Pharmacology and Physiology, University of Rochester Medicine, Rochester, NY, USA 14624.ORCID 0000-0001-9560-2941

Funding

TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
Neural mechanisms regulating glucose homeostasisR01DK135621 · NIDDK · UNIVERSITY OF ROCHESTER · PI Yumei Feng Earley · 2023 to 2026
$2.2M
NHLBI NIH HHS R01 HL122770NHLBI NIH HHS R35 HL155008NIDDK NIH HHS R01 DK135621
6 · The paper itself

Abstract

Background: Myogenic tone is a fundamental property of resistance arteries that stabilizes tissue perfusion by coupling intraluminal pressure to smooth muscle cell (SMC) depolarization, Ca Methods: We combined droplet digital PCR, a newly generated Results: Conclusions: These findings show that TRPM4 is essential for pressure-induced SMC depolarization and myogenic constriction in the resistance vasculature.

Identifiers

PMID42327028
PMCPMC13278013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.