ArticleCardiology research2026
Nonvalvular Atrial Fibrillation and Anticoagulation in the Elderly: A Retrospective Cohort Study.
Article in Cardiology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atrial fibrillation (AF) is associated with a substantially increased risk of ischemic stroke and systemic embolism particularly in elderly patients. Understanding real-world patterns of anticoagulation (AC) use in elderly population is critical. Methods: This is a retrospective, single-center, chart review study that included patients who had nonvalvular AF between 2021 and 2024. Patients were divided into two groups according to age: 50-75 years old and 76-89 years old. Primary endpoint was AC underutilization, which was defined by the presence of all the following conditions: 1) CHA Results: A total of 6,386 patients were included. Among them, 3,306 patients were 50-75 years old, and 3,080 patients were 76-89 years old. Patients in age group 76-89 had a 4.547-fold higher odds ratio (OR = 4.547; 95% confidence interval (CI), 3.827-5.403) to have AC underutilization than those in age group 50-75. Patients in age group 76-89 were 108% (OR = 2.077; 95% CI, 1.818-2.374) more likely to have AC appropriateness than those in age group 50-75. History of bleeding (OR = 10.582; 95% CI, 6.467-17.315; P < 0.001) and glomerular filtration rate (GFR) (OR = 0.985; 95% CI, 0.982-0.988; P < 0.001) were independent predictors of appropriateness. Similar, history of bleeding (OR = 2.402; 95% CI, 1.666-3.462; P < 0.001) and GFR (OR = 1.006; 95% CI, 1.001-1.010; P = 0.0185) were also independent predictors of underutilization. Conclusions: Patients in age group 76-89 were more likely to have AC underutilization than patients in age group 50-75. History of bleeding and GFR were independent predictors of appropriateness and underutilization. These findings highlight the ongoing challenge of balancing stroke prevention and bleeding risk in elderly AF patients and underscore the importance of guideline-directed, individualized AC strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.