Evidence map›Paper›PMID 42326826›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Host Genetic Regulation of NLRP3 Inflammasome Cytokines Reveals Immune and Vascular Pathways in HIV.

Ryan Chung, Namratha Shivani Chalasani, Alton S Barbehenn, Erik Lundgren, Sonia Savur, Sayane Shome, Caroline H Sheikhzadeh, Sannidhi Sarvadhavabhatla, Maria Sophia Donaire, Vivian Pae and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Ryan ChungCenter for Computational Biology, University of California Berkeley, Berkeley, CA.ORCID 0000-0002-6799-3866
Namratha Shivani ChalasaniDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.ORCID 0009-0003-2204-3562
Alton S BarbehennDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.ORCID 0009-0000-3364-7204
Erik LundgrenDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Sonia SavurDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.ORCID 0009-0008-0418-6144
Sayane ShomeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Caroline H SheikhzadehDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Sannidhi SarvadhavabhatlaDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Maria Sophia DonaireDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Vivian PaeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.
Xiuping ChuInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Daniel WinderCellular Translational Research Core, Clinical Translational Sciences Institute, University of Utah, Salt Lake City, UT.
Colin T MaguireCellular Translational Research Core, Clinical Translational Sciences Institute, University of Utah, Salt Lake City, UT.
Senay TopalInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Anuradha GanesanInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Joseph M YabesInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Derek T LarsonInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Tahaniyat LalaniInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Evan C EwersDivision of Infectious Diseases, Tripler Army Medical Center, Honolulu, HI.
Rhonda E ColomboInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.
Eli DuganGladstone Institutes, San Francisco, CA, USA.
Ujjwal RathoreGladstone Institutes, San Francisco, CA, USA.
Alexander MarsonGladstone Institutes, San Francisco, CA, USA.
Brian K AganInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD.ORCID 0000-0002-5114-1669
Jeffrey A TomalkaDepartment of Pathology and Laboratory Medicine, Emory School of Medicine, Atlanta, GA.
Rafick P SekalyDepartment of Pathology and Laboratory Medicine, Emory School of Medicine, Atlanta, GA.
Nilah M IoannidisCenter for Computational Biology, University of California Berkeley, Berkeley, CA.ORCID 0000-0001-9628-8229
Sulggi A LeeDepartment of Medicine, Division of HIV, Infectious Diseases & Global Medicine, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-1560-2250

Funding

Project 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALAN D FRANKEL · 2022 to 2026
$35.7M
CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
In Vivo Imaging and Post-Mortem Study of Methamphetamine Use on Immune Dysfunction and HIV Reservoir Transcription among People with HIV on ARTRM1DA063218 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Amelia N Deitchman, Timothy Jensen Henrich · 2025 to 2026
$4.7M
Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV diseaseR01AI143464 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2019 to 2023
$4.0M
Center for Critical Assessment of Genome InterpretationU24HG007346 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRENNER, STEVEN E, IOANNIDIS, NILAH MONNIER · 2020 to 2025
$3.8M
Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV diseaseR61DA047024 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2018 to 2021
$2.7M
Methamphetamine Activation of Inflammasome and Altered immunity in HIV (MAIA) StudyR01DA062380 · NIDA · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Sulggi Angela Lee, Susan Pereira Ribeiro · 2024 to 2026
$2.2M
Short-term and long-term effects of methamphetamine exposure on residual viral transcription during treated HIV diseaseR33DA047024 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2024 to 2025
$1.7M
A pharmacogenomics study of HIV latency: the role of PD-1 signalingK23GM112526 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, SULGGI ANGELA · 2014 to 2018
$908k
ACCOMPLISH (Applied Coaching of COMPutational Learners In Substance use and HIV) Mentoring ProgramK24DA064477 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sulggi Angela Lee · 2025 to 2026
$412k
NCATS NIH HHS UM1 TR004409NHGRI NIH HHS U24 HG007346NIAID NIH HHS R01 AI143464NIAID NIH HHS U54 AI170792NIAID NIH HHS Y01 AI005072NIDA NIH HHS K24 DA064477NIDA NIH HHS R01 DA062380NIDA NIH HHS R33 DA047024NIDA NIH HHS R61 DA047024NIDA NIH HHS RM1 DA063218NIGMS NIH HHS K23 GM112526
6 · The paper itself

Abstract

People with HIV exhibit elevated inflammation and cardiovascular risk despite antiretroviral therapy. To define the genetic architecture of inflammasome-associated inflammation, we performed whole-genome sequencing and quantified plasma IL-6, IL-1β, and IL-18 in 1,000 ART-suppressed PWH from the U.S. Military HIV Natural History Study. Genome-wide analyses identified 14 loci implicating antiviral defense (

Indexed as

antiretroviral therapygenomewide association study (GWAS)HIVinterleukin-18 (IL-18)interleukin-1 beta (IL-1β)interleukin-6 (IL-6)NLRP3 inflammasometranscriptomewide association study (TWAS)

Identifiers

PMID42326826
PMCPMC13278269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.