Evidence map›Paper›PMID 42326782›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Multi-region sampling of the human small intestine using an ingestible device.

Beverly Fu, Leila Bronnert DeSchepper, Jiawei Sun, Saria A McKeithen-Mead, Bennett Kapili, Pablo Ochoa-Andersen, Sean Paul Spencer, Touran Fardeen, Maya Ricardo, Vanessa El Kamari and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Beverly FuDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2345-6911
Leila Bronnert DeSchepperDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0002-8491-9999
Jiawei SunDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7054-6338
Saria A McKeithen-MeadDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Bennett KapiliEnvivo Bio, Inc., San Francisco, CA 94107, USA.
Pablo Ochoa-AndersenDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16801, USA.
Sean Paul SpencerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7328-5399
Touran FardeenDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-6050-740X
Maya RicardoEnvivo Bio, Inc., San Francisco, CA 94107, USA.
Vanessa El KamariDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sidhartha SinhaDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-5104-6410
David A RelmanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8331-1354
Jessica A GrembiDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16801, USA.ORCID 0000-0001-6142-4913
Dari ShalonEnvivo Bio, Inc., San Francisco, CA 94107, USA.ORCID 0000-0003-2646-6215
Sylvie EstrelaDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-1946-3657
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8043-8138

Funding

MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Illuminating the dark matter of the human small intestinal microbiotaDP1DK147449 · NIDDK · STANFORD UNIVERSITY · PI KERWYN C. HUANG · 2025 to 2026
$2.2M
NIAID NIH HHS T32 AI007328NIDDK NIH HHS DP1 DK147449
6 · The paper itself

Abstract

The human small intestine (SI) plays a central role in nutrient processing, host-microbe interactions, and immune regulation, yet remains poorly characterized due to the lack of minimally disruptive sampling methods. Here, we present a protocol for deploying, recovering, and analyzing samples collected using an ingestible device that enables multi-region, lumen-targeted SI sampling during normal digestion. The device incorporates a ~30-cm collapsible tube wound into pH- or time-responsive layers that sequentially unfurl

Identifiers

PMID42326782
PMCPMC13278218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.