Fluorous-Directed Clamping Stabilizes Triple-Helical DNA.

Andrea Taladriz-Sender, Michael Brazzill, Jamie M Withers, Alasdair W Clark, Glenn A Burley, David A Rusling

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Sequence-Specific Targeting of GC-Rich Gene Loci by Parallel Triplex-Forming Oligonucleotides Containing a Modified Nucleobase.bioRxiv : the preprint server for biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea Taladriz-SenderDepartment of Pure Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, U.K.ORCID https://orcid.org/0000-0002-8274-4761

Michael BrazzillSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, U.K.

Jamie M WithersDepartment of Pure Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, U.K.

Alasdair W ClarkJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, U.K.ORCID https://orcid.org/0000-0001-9797-5776

Glenn A BurleyDepartment of Pure Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, U.K.

David A RuslingSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, U.K.ORCID https://orcid.org/0000-0002-7442-686X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we present a strategy to stabilize DNA triplexes by the attachment of perfluorinated tails to the 3' and/or 5' end of oligodeoxyribonucleotides. The tails preferentially associate with one another via the "fluorous effect" without compromising sequence selectivity. The most stable complex resulted in a dramatic 14 °C increase in melting temperature at neutral pH. This orthogonal recognition approach broadens the applications of triplex DNA in diagnostics, therapy, and DNA nanotechnology.

Identifiers

PMID42326703

DOI10.1021/acsomega.6c00803

PMCPMC13280840

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.