ArticleACS omega2026
Low-Level Laser Mitigates Cisplatin-Induced Oxidative Stress and Apoptosis via AMPK-Mediated Autophagy in PC12 Cells.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Platinum-based chemotherapeutic agents, such as cisplatin, form the cornerstone of many modern anticancer treatment regimens. Despite their clinical effectiveness, long-term use is often limited by dose-related side effects, notably peripheral neuropathy, which significantly impacts patient quality of life and restricts treatment success. Neuroprotective strategies are still limited. Low-level laser (LLL) therapy, also known as photobiomodulation, has recently gained recognition as a noninvasive approach capable of reducing various tissue damages, including nerve injuries. However, the cellular and molecular mechanisms behind its protective effects in chemotherapy-induced neurotoxicity are not yet fully understood. In this study, we examined the neuroprotective effects of LLL in an in vitro model of cisplatin toxicity using PC12 neuronal cells. PC12 neuronal cells were pretreated with LLL irradiation at 660 nm and 5 J/cm
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