ArticleACS omega2026
Stimuli-Responsive Polypyrrole Hydrogel Integrated into a Mg Battery for Controlled Drug Release.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
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Abstract
Although stimulus-responsive drug delivery systems allow for precise drug release, electro-assisted delivery methods are seldom incorporated into transdermal platforms, highlighting a major research gap. In this work, we developed a self-powered, controllable drug delivery platform using a conductive gelatin methacryloyl-polyacrylamide-polypyrrole hydrogel (GPP) as the cathode in a magnesium battery. The GPP hydrogel was synthesized via UV cross-linking and in situ polymerization, exhibiting a compact porous structure, enhanced mechanical strength (fracture strain: 234%), stable electrochemical performance, and excellent cytocompatibility. It also functioned as a sensitive strain sensor (gauge factor: 1.14). Drug release was precisely tuned by electrical stimulation, increasing from 0.2 mg/g at 0 V to nearly 1.6 mg/g at -0.8 V within 180 min. The integrated Mg-GPP battery powered drug delivery effectively, achieving a 5-fold enhancement over passive diffusion. This system provides a promising strategy for advanced personalized transdermal therapy with combined electrically controlled release and motion sensing capability.
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Registered trials
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