Comparative Effects of Post-Extrusion Annealing and PLLA Surface Modification on the Degradation Behavior and Endothelial Responses of ZK60 Magnesium Alloy.

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guan-Lin WuDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, Daxue Rd., East Dist., Tainan City 701401, Taiwan.ORCID https://orcid.org/0000-0001-9543-583X

Chin-En YenDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, Daxue Rd., East Dist., Tainan City 701401, Taiwan.ORCID https://orcid.org/0009-0008-3182-3946

Ming-Long YehDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, Daxue Rd., East Dist., Tainan City 701401, Taiwan.ORCID https://orcid.org/0000-0001-6942-060X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biodegradable magnesium alloys have emerged as attractive materials for cardiovascular stents due to their mechanical compatibility with vascular tissues and inherent biocompatibility. Despite these advantages, their clinical translation is hindered by rapid and localized degradation in physiological environments. To address this challenge, the present study systematically compares the effects of bulk postprocessing and surface modification on the degradation behavior and biological performance of extruded ZK60 magnesium alloy. Hot-extruded ZK60 (E-ZK), postextrusion annealed ZK60 (A-ZK), and poly-(l-lactic acid)-coated ZK60 (P-ZK) were investigated through a stepwise experimental design. The influence of annealing on intrinsic mechanical properties was first examined, followed by electrochemical analysis, immersion degradation testing, and endothelial cell evaluations across all material conditions. While postextrusion annealing altered the mechanical response of ZK60, it showed limited effectiveness in mitigating degradation or enhancing endothelial interactions. In contrast, the PLLA surface coating significantly reduced electrochemical reactivity. It decreased the corrosion current density from approximately 151-223 μA/cm

Identifiers

PMID42326660

DOI10.1021/acsomega.6c02648

PMCPMC13280883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.