Evidence map›Paper›PMID 42326630›Full record

ArticleACS omega2026

Leucine Aminopeptidase-Activatable Photosensitizer Enables Enzyme-Responsive Photodynamic Therapy in Neuroblastoma.

Osman Karaman, Dilay Kepil, Asena Sayin, Mehrdad Forough, Erva Ozkan, Zubeyir Elmazoglu, Gorkem Gunbas

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Osman KaramanDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.
Dilay KepilDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.
Asena SayinDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.
Mehrdad ForoughDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.
Erva OzkanDepartment of Biochemistry, Ankara Medipol University, Altındağ, Ankara 06050, Türkiye.
Zubeyir ElmazogluDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.
Gorkem GunbasDepartment of Chemistry, Middle East Technical University, Çankaya, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0003-2279-3032

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a minimally invasive and tumor-selective treatment modality; however, despite notable progress in several cancer types, effective treatment options for brain tumors remain limited. Although explored only in a limited number of studies, the intrinsic selectivity of photosensitizers bearing activatable groups makes PDT an attractive strategy for brain cancers. Here, we report, for the first time, the photodynamic efficacy of a leucine aminopeptidase (LAP)-activatable iodinated resorufin derivative (

Identifiers

PMID42326630
PMCPMC13280826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.