ArticleACS omega2026
Revisiting Stereocontrol through Ligand-Directed Non-Covalent Interactions in the Asymmetric Synthesis of Tetrahydrofuran Cores via Tsuji-Trost Asymmetric Allylic Alkylation.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Five-membered oxygenated heterocycles, such as substituted tetrahydrofurans (THFs), are important structural motifs in bioactive compounds and can be efficiently accessed through palladium-catalyzed asymmetric allylic alkylation (AAA). In this context, the desymmetrization of mesodiols represents a powerful strategy for the stereocontrolled construction of chiral THF frameworks. Herein, we present a combined experimental and computational study aimed at elucidating the origin of an unusual diastereoselectivity inversion observed in this reaction. While ligands of the Trost family are generally considered interchangeable when sharing the same chiral information, experimental results show that switching between
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