Evidence map›Paper›PMID 42326594›Full record

ReviewArchives of rehabilitation research and clinical translation2026

Effects of Resistance Training on Breast Cancer-Related Lymphedema: A Meta-Analysis.

Shuwei Wu, Chen Zhong, Zhaoxing Liu

Abstract readReview
In one paragraph

Review in Archives of rehabilitation research and clinical translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shuwei WuDepartment of Nursing, School of Health, Hebei Oriental University, Langfang, Hebei.
Chen ZhongSenior Department of Burns and Plastic Surgery, Chinese PLA General Hospital, Beijing, China.
Zhaoxing LiuSenior Department of Burns and Plastic Surgery, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To determine the effectiveness of resistance training (RT) on the incidence, severity, and objective physiological indicators of breast cancer-related lymphedema (BCRL), and to assess its impact on limb function. Data sources: A systematic search was conducted in PubMed, Embase, Web of Science, Medline, Sinomed, China National Knowledge Infrastructure (CNKI), Wanfang, VIP Information Co., Ltd. (VIP), and the Chinese Medical Journal full-text database from inception to August 1, 2025. Study Selection: Randomized controlled trials involving adults with breast cancer who were at risk of or had established BCRL, and comparing RT with nonresistance exercise, usual care, or alternative management approaches. A total of 38 Randomized controlled trials involving 4843 patients were included. Data Extraction: Two reviewers independently screened the studies, extracted data using a standardized form, and assessed the risk of bias using the Cochrane Risk of Bias 2 tool. Data Synthesis: Statistical analyses were performed using RevMan 5.4. RT significantly reduced the incidence of lymphedema (odds ratio [OR]=0.25, 95% CI, 0.19-0.32) and moderate-to-severe lymphedema (OR=0.21, 95% CI, 0.16-0.29). It also decreased upper limb volume (mean difference [MD]=-152.37, 95% CI, -153.81 to -150.94) and circumference differences (MD=-1.51, 95% CI, -1.62 to -1.41), while improving lymphatic drainage volume (MD=5.03, 95% CI, 4.67-5.39) and the rate of excellent or good limb function (OR=4.23, 95% CI, 2.72-6.57). Subgroup analyses revealed that a short-duration, high-frequency training paradigm and combined therapy regimens produced the most pronounced protective effects. Conclusions: RT is a safe and effective intervention that significantly reduces the risk and severity of BCRL while improving limb volume, lymphatic function, and shoulder mobility. For optimal benefit in clinical practice, progressive RT should be delivered using a "short-duration, high-frequency" model integrated into combined therapy protocols.

Indexed as

Breast cancer-related lymphedemaCombined therapyExercise dosageMeta-analysisRehabilitationResistance training

Identifiers

PMID42326594
PMCPMC13282808

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.