ArticleArchives of rehabilitation research and clinical translation2026
Multidimensional Assessment of Fall Risk Using the Timed Up and Go Test and Complementary Measures in a Charcot-Marie-Tooth Type 1A Neuropathy.
Article in Archives of rehabilitation research and clinical translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the relationship between the occurrence of falls and the time taken to perform the Timed Up and Go (TUG) test in a population of patients with Charcot-Marie-Tooth disease type 1A (CMT1A). Design: We conducted a longitudinal, single-center, exploratory study involving adult patients with CMT1A, followed for 1 year. Physical, functional, and analytical tests, including the TUG test, gait analysis, and muscle strength assessment, were performed at baseline, 6 months, and 12 months. Patients also completed questionnaires on physical capabilities, fatigue, falls, and the impact on quality of life and psychological health. The study was conducted between September 2020 and February 2025. Setting: This study was conducted at a university hospital. Participants: Patients (n=40) included in this study had to be adults, have a molecular biology-confirmed diagnosis of CMT1A, have quadriceps strength >2 of 5, and have a proficient oral and written understanding of French. Interventions: Not applicable. Main outcome measures: The primary outcome was the time (in s) required to complete the TUG test, analyzed according to the frequency of self-reported falls. Secondary outcome measures included balance performance assessed with the Berg Balance Scale (BBS) and walking endurance evaluated by the distance covered during the 6-minute walk test (6MWT). Physical, functional, and analytical tests were conducted at baseline, 6 months, and 12 months. Results: We included 40 patients with CMT1A, predominantly women (62.5%), with a median (interquartile range) age of 52 (42-67) years. Analysis of the TUG test results according to fall frequency revealed no significant difference between groups (no fall, 1-2 falls, and >2 falls) with respect to the median (interquartile range) time: 9.3 (6.9-10.8), 9.0 (7.5-10.4), and 9.5 (7.8-11.0) seconds, respectively ( Conclusions: When used alone, the TUG test is not a suitable tool for fall risk screening in patients with CMT1A. Balance (BBS) and walking endurance (6MWT) also remained stable over 1 year. Global assessment is crucial for detecting physical impairments and preventing falls. A future study could include a larger sample and a more precise categorization of falls.
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