Evidence map›Paper›PMID 42326549›Full record

ArticleInfectious diseases & immunity2024

Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome-Associated Toxoplasmic Encephalitis: A Prospective Observational Multicenter Study in China.

Yao Li, Haidong Jiang, Yanming Zeng, Yanqiu Lu, Siyuan Chen, Yulin Zhang, Zhongsheng Jiang, Tongtong Yang, Shuiqing Liu, Yaokai Chen

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Article in Infectious diseases & immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yao LiDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
Haidong JiangDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
Yanming ZengDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
Yanqiu LuDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
Siyuan ChenDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
Yulin ZhangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Zhongsheng JiangDepartment of Infectious Diseases, Liuzhou People's Hospital, Liuzhou 545006, Guangxi, China.
Tongtong YangDepartment of Infectious Disease, The Public Health Clinical Center of Chengdu, Chengdu 610066, Sichuan, China.
Shuiqing LiuDepartment of Infectious Disease, Guiyang Public Health Clinical Center, Guiyang 550004, Guizhou, China.
Yaokai ChenDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Toxoplasmic encephalitis (TE) is the most frequent cause of expansive brain lesions among patients with acquired immunodeficiency syndrome (AIDS). However, the optimal timing of antiretroviral therapy (ART) initiation in these patients remains controversial. This study aims to investigate the differences in outcomes of ART initiation at different times, in order to help clarify the treatment timing of AIDS-associated TE. Methods: This multicenter prospective observational study included 87 patients recruited from 11 research centers in China (from March 2019 to December 2022). Of the patients, 38 were assigned to the early ART group (initiating ART within 2 weeks after anti- Results: The number of deaths (1 Conclusion: In patients with AIDS-associated TE, early ART initiation was not significantly different from deferred ART initiation in terms of incidence of mortality, IRIS, and HIV virological and immunological outcomes.

Indexed as

HIVImmunological responseTiming of antiretroviral therapyToxoplasma gondiiVirological outcome

Identifiers

PMID42326549
PMCPMC13277566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.