ArticleResearch square2026
PAD4 deletion in synovial macrophages exacerbates pathology in inflammatory arthritis.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Citrullination by peptidylarginine deiminase (PAD) enzymes is a post-translational protein modification implicated in the etiopathogensis of rheumatoid arthritis. Of the five known PAD isoforms, PAD4 is expressed in the nucleus of innate immune cells including synovial macrophages, and studies have shown citrullination of intracellular proteins such as transcription factors and histones can polarize cell phenotype. Here, we report how systemic and local deletion of PAD4 in synovial macrophages from PAD4
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