Evidence map›Paper›PMID 42326532›Full record

ArticleResearch square2026

MHub.ai: A Standardized Platform for Reproducible AI Research in Medical Imaging.

Leonard Nürnberg, Dennis Bontempi, Suraj Pai, Curtis Lisle, Steve Pieper, Ron Kikinis, Sil van de Leemput, Rahul Soni, Gowtham Murugesan, Cosmin Ciausu and 10 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Leonard NürnbergArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Dennis BontempiArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Suraj PaiArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Curtis LisleKnowledgeVis, LLC, Maitland, FL, USA.
Steve PieperIsomics, Inc., Cambridge, MA, USA.ORCID 0000-0003-4193-9578
Ron KikinisDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sil van de LeemputImaging Department, Radboud University Medical Center, Nijmegen, The Netherlands.
Rahul SoniBAMF Health LLC, Grand Rapids, MI, USA.
Gowtham MurugesanBAMF Health LLC, Grand Rapids, MI, USA.
Cosmin CiausuArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Miriam GroeneveldImaging Department, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-2783-0085
Felix J DorfnerDepartment of Radiology, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Jue JiangDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Aneesh RangnekarDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Harini VeeraraghavanDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Joeran S BosmaImaging Department, Radboud University Medical Center, Nijmegen, The Netherlands.
Keno BressemRadiology and Nuclear Medicine, CARIM & GROW, Maastricht University, Maastricht, Netherlands.
Raymond MakArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Andrey FedorovDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hugo Jwl AertsArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2122-2003

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Lymph Node Quantification System for Multisite Clinical TrialsR01CA235589 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GORDON J HARRIS, Ron Kikinis · 2019 to 2026
$4.5M
Quantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5M
Genotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3M
Safer lung cancer radiotherapy delivery using novel artificial intelligence methodsR01CA258821 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Harini Veeraraghavan · 2022 to 2026
$2.5M
Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancerK08DE030216 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI KANN, BENJAMIN HARRIS · 2021 to 2025
$841k
NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INCI NIH HHS R01 CA235589NCI NIH HHS R01 CA258821NCI NIH HHS U01 CA190234NCI NIH HHS U01 CA209414NCI NIH HHS U24 CA194354NIDCR NIH HHS K08 DE030216
6 · The paper itself

Abstract

Artificial intelligence (AI) has the potential to transform medical imaging by automating image analysis and accelerating clinical research. However, research and clinical use are limited by the wide variety of AI implementations and architectures, inconsistent documentation, and reproducibility issues. Here, we introduce MHub.ai, an open-source, container-based platform that standardizes access to AI models with minimal configuration, promoting accessibility and reproducibility in medical imaging. MHub.ai packages models from peer-reviewed publications into standardized containers that support direct processing of DICOM and other formats, provide a unified application interface, and embed structured metadata. Each model is accompanied by publicly available reference data to confirm model operation. MHub.ai includes an initial set of segmentation, prediction, and feature extraction models for different modalities. The modular framework enables adaptation of any model and supports community contributions. We demonstrate the utility of the platform through comparative evaluation of lung segmentation models on public clinical data, and publicly release the generated segmentations and evaluation metrics as interactive dashboards to emphasize transparency and to enable case-level inspection. By enabling side-by-side benchmarking with identical execution commands and standardized outputs, MHub.ai reduces technical friction for model execution, evaluation, and comparison.

Identifiers

PMID42326532
PMCPMC13278289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.