Evidence map›Paper›PMID 42326513›Full record

ArticleResearch square2026

Interconnected influences of diet, gut microbiome, and metabolome on cognition across three metabolomics platforms.

Lora Khatib, Lucas Patel, Siamak MahmoudianDehkordi, Jennifer S Labus, Julius Agongo, Kamil Borkowski, Madison Ambre, Christopher Brydges, Leyla Schimmel, Colette Blach and 17 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Lora KhatibDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-6998-8278
Lucas PatelDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-8607-2782
Siamak MahmoudianDehkordiDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Jennifer S LabusG. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, California, USA.ORCID 0000-0002-6634-2551
Julius AgongoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Kamil BorkowskiGenome Center, University of California, Davis, Davis, CA 95616, USA.
Madison AmbreDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Christopher BrydgesDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Leyla SchimmelDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Colette BlachDuke Molecular Physiology Institute, Duke University, Durham, NC, 27701, USA.
Alzheimer Gut Microbiome Project Consortium
Naama KaruTasmanian Independent Metabolomics and Analytical Chemistry Solutions (TIMACS), Hobart, Tasmania, 7008, Australia.
Matthew TaylorDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas 66160.
Edgar DiazDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Jared BroschDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-6578-0584
Barbara BendlinWisconsin Alzheimer's Disease Research Center, University of Wisconsin, Madison, WI.ORCID 0000-0002-0580-9875
Russell SwerdlowUniversity of Kansas Alzheimer's Disease Research Center, Fairway, Kansas 66205.ORCID 0000-0003-2948-7230
Victor W HendersonDepartments of Epidemiology & Population Health and of Neurology & Neurological Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0003-1198-9240
Doris Suyu ChenUniversity of California Davis Alzheimer Disease Research Center, Sacramento, CA.
Andrew J SaykinIndiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-1376-8532
Suzanne CraftWake Forest University School of Medicine Alzheimer's Disease Research Center, Winston-Salem, NC, 27157.
James BrewerShiley-Marcos Alzheimer's Disease Research Center, Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Thomas WisniewskiNew York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-3379-8966
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1810-9763
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Rima Kaddurah-DaoukDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.ORCID 0000-0003-1858-5732
Rob KnightDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI William J. Jagust · 2016 to 2026
$226.7M
Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ROB KNIGHT, Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Mariet Allen · 2023 to 2026
$42.0M
Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2023 to 2026
$39.4M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) Mental Health Administrative SupplementU24HL169645 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI GARNET L. ANDERSON, Kwun Chuen Gary Chan · 2023 to 2026
$28.9M
Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Arline Faustin · 2020 to 2026
$28.4M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
NHLBI NIH HHS U24 HL169645NHLBI NIH HHS UH3 HL169648NIA NIH HHS F30 AG094275NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG046171NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG068193NIA NIH HHS R01 AG072582NIA NIH HHS R01 AG084535NIA NIH HHS R01 AG089169NIA NIH HHS R01 AG092591NIA NIH HHS R21 AG093006NIA NIH HHS RF1 AG051550NIA NIH HHS RF1 AG057452NIA NIH HHS RF1 AG058942NIA NIH HHS RF1 AG059093NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG061359NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG063744NIA NIH HHS U19 AG074879NIA NIH HHS U19 AG079774NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIGMS NIH HHS T32 GM007198NINDS NIH HHS R01 NS086085NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

Cognitive impairment is increasing with global aging, yet mechanisms linking diet, the gut microbiome, and metabolism to cognitive function remain unclear. To investigate a diet-microbiome-metabolome axis associated with cognition, we integrated fecal metagenomics, diet, and multi-platform plasma metabolomics in 505 older adults from four ADRCs. Several microbes broadly associated with circulating metabolites were also linked to multiple measures of cognitive performance. These taxa exhibited coordinated metabolic signatures, with cognition-positive microbes associated with antioxidant, lipid, and microbial-host co-metabolites, and microbes negatively associated with cognition were linked to inflammatory and aromatic amino acid-derived metabolites. Dietary patterns, particularly the Healthy Eating Index Greens and Beans component, were associated with microbial composition and metabolomic structure. Mediation analyses supported a diet-microbe-metabolite-cognition pathway, while metabolites remained associated with cognition after accounting for microbial features. These findings highlight the metabolome as a central integrator of diet, microbial activity, and cognitive function.

Identifiers

PMID42326513
PMCPMC13278265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.