Evidence map›Paper›PMID 42326509›Full record

ArticleResearch square2026

Nociceptor neurons suppress antitumor immunity in breast cancer.

Yue Wu, Maryam Ahmadi, Ania Bogoslowski, Laura Brabenec, Jumana Abbadi, Annie Doyle, Beatriz G S Rocha, Amin Reza Nikpoor, Sara Nikoofal-Sahlabadi, Vera Thiel and 24 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Yue WuCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Maryam AhmadiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Ania BogoslowskiDepartment of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Laura BrabenecDepartment of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
Jumana AbbadiDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Annie DoyleDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Beatriz G S RochaDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Amin Reza NikpoorDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Sara Nikoofal-SahlabadiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Vera ThielHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg University, Heidelberg, Germany.
Elisa PretoDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Sheu O SulaimanInstitute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Migmar TsamchoeLady Davis Institute, Jewish General Hospital, McGill University, Centre for Translational Research, Montreal, QC, Canada.
Olga BednovaLady Davis Institute, Jewish General Hospital, McGill University, Centre for Translational Research, Montreal, QC, Canada.
Alissa DoryDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Lisa A McIlvriedHillman Cancer Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Tuany EichwaldDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Tamara McErlainDepartment of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
Mohammad BaloodDepartment of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.
Christos BoutopoulosCentre de recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
Moutih RafeiDepartment of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.ORCID 0000-0003-4457-1350
Paola VermeerCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA.ORCID 0000-0003-2370-8223
Aeson ChangMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Erica SloanMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.ORCID 0000-0002-2355-1433
Moran AmitDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9720-7766
Josef PenningerDepartment of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-8194-3777
H Uri SaragoviLady Davis Institute, Jewish General Hospital, McGill University, Centre for Translational Research, Montreal, QC, Canada.
Andreas TrumppHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-6212-3466
Nicole N ScheffHillman Cancer Center, Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-5587-4990
Karen DixonDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID 0000-0001-7811-5439
Maureen CoxDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Alexander BirbrairDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1015-2561
Sébastien TalbotDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0000-0001-9932-7174
Jeremy BornigerCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-5419-0271

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI David A Tuveson · 1987 to 2026
$118.9M
Central mechanisms of glucocorticoid circadian rhythm dysfunction in breast cancerR01CA286651 · NCI · COLD SPRING HARBOR LABORATORY · PI Jeremy Borniger · 2024 to 2026
$2.3M
Defining and exploiting therapeutically the role of the neuropeptide receptor PAC1 in tumor-infiltrating pericytes that drives melanoma progression.R37CA300434 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexander Birbrair · 2026 to 2026
$509k
NCI NIH HHS P30 CA014520NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA286651NCI NIH HHS R37 CA300434
6 · The paper itself

Abstract

Peripheral nerves are emerging regulators of the tumor microenvironment, but how sensory innervation shapes breast cancer immunity remains poorly defined. Here we show that triple-negative breast cancers (TNBCs) co-opt nociceptor neurons to suppress antitumor immunity and promote disease progression. Across orthotopic TNBC models, we found that primary tumors and tumor-draining lymph nodes were densely innervated by CGRP

Identifiers

PMID42326509
PMCPMC13278325

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.