Evidence map›Paper›PMID 42326466›Full record

ArticleImmunotherapy advances2026

NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses.

Akhil Shukla, Mohammad Moradzad, Akouavi Julite Irmine Quenum, Jean-François Lucier, Anny Armas Cayarga, Dominique Lévesque, François-Michel Boisvert, Thomas A Kufer, Sheela Ramanathan, Subburaj Ilangumaran

Abstract read
In one paragraph

Article in Immunotherapy advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akhil ShuklaDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID https://orcid.org/0009-0000-3524-7175
Mohammad MoradzadDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Akouavi Julite Irmine QuenumDepartment of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Jean-François LucierDepartment of Biology, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Anny Armas CayargaDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Dominique LévesqueDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
François-Michel BoisvertDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Thomas A KuferDepartment of Immunology, Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.ORCID https://orcid.org/0000-0003-4563-0412
Sheela RamanathanDepartment of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID https://orcid.org/0000-0002-4868-3934
Subburaj IlangumaranDepartment of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID https://orcid.org/0000-0002-7563-576X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8 Materials and methods: Results: NLRC5-expressing tumors were efficiently controlled in both Conclusion: NLRC5 expression in APCs is dispensable for NLRC5-dependent antitumor immunity. NLRC5-dependent tumor control requires both CD8

Indexed as

CD8+ T cellsimmune evasionMHC-INK cellsNLRC5tumor microenvironment

Identifiers

PMID42326466
PMCPMC13282443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.