Evidence map›Paper›PMID 42326462›Full record

ArticleRegenerative biomaterials2026

Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects.

Dongbiao Chang, Zhenfan Bai, Linke Li, Jun Sheng, Hongzhi Fang, Zian Wang, Zili Guo, Hui Zhang, Xinxi Yang, Rui Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dongbiao ChangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Zhenfan BaiInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Linke LiInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Jun ShengDepartment of Orthopedic, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China.
Hongzhi FangThe Center of Obesity and Metabolic Diseases, Department of General Surgery, The Third People's Hospital of Chengdu & The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610014, China.
Zian WangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Zili GuoInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Hui ZhangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Xinxi YangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Rui ChenInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Huan TanInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.
Mengyuan WangState Key Laboratory of Oral Diseases and National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Jie WengInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China.ORCID https://orcid.org/0000-0002-7034-3215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infected bone defects present a significant clinical challenge, as persistent bacterial burden and exacerbated inflammatory response induce microenvironmental acidification, which severely compromises tissue regeneration. Therefore, this study aims to construct a smart platform to regulate the local microenvironment and achieve the therapeutic effect of bone regeneration. Here, pitaya‑inspired compartmentalized microspheres (IBPR‑CuTA) were developed to provide spatiotemporally controlled pH‑responsive release of Cu

Indexed as

antibacterial activitycompartmentalized microspheresinfected bone defect repairreprogrammed macrophagespatiotemporally pH-responsive release

Identifiers

PMID42326462
PMCPMC13278850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.