ArticleNeurophotonics2026
Measurement of the absolute value of the optical birefringence of myelin in primate brain tissue.
Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Significance: Researchers require quantitative biomarkers to accurately identify neurodegenerative diseases and quantitatively monitor disease progression. The structural anisotropy of myelin leads to strong optical birefringence, enabling quantitative imaging with polarized-light microscopy imaging for detailed myelin assessment in neurodegenerative disease states and aging studies. Aim: Our aim is to measure the absolute refractive index difference (birefringence) of the myelin sheath of primate brain tissue using birefringence microscopy (BRM). Approach: Three-micron cryo-sectioned samples from the paraformaldehyde-fixed corpus callosum of a 22-year-old male rhesus macaque were analyzed using a BRM system. To quantify the absolute birefringence, transversely oriented axons were imaged with a 40× objective under red light-emitting diode illumination ( Results: The myelin birefringence was determined to be Conclusions: This absolute birefringence value enables quantification of myelin volume fraction and assessment of myelin loss in
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