ArticleFrontiers in microbiology2026
From probiotic depletion to inflammatory cascade: multi-omics reveals the temporal progression of sleep deprivation-induced gut-liver axis disruption in mice.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Sleep deprivation (SD) is increasingly recognized as a risk factor for metabolic and hepatic disorders, yet the temporal dynamics linking gut dysbiosis to liver injury remain poorly characterized. Methods: In this study, we established a platform-based SD model in a total of 24 C57BL/6J mice ( Results: Our results revealed a temporally ordered three-stage cascade of gut-liver axis disruption. In week 1, core probiotics including Discussion: These findings describe a "protective loss-homeostatic decoupling-inflammatory signature" descriptive model. Because these findings are based on correlation analyses in a mouse model without causal validation, further mechanistic and interventional studies are required before any clinical implications can be drawn.
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