Evidence map›Paper›PMID 42326401›Full record

ArticleFrontiers in microbiology2026

IL-4-mediated monocyte differentiation modulates CD163 expression and PRRSV infection.

Narae Kim, Young-Jun Ju, Yoon-Chul Kye, Cheol Gyun Kim, Young Jin Pyung, Da-Jeong Park, Sun-Jong You, Hakhyun Ka, Seung Hyun Han, Cheol-Heui Yun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Narae KimDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Young-Jun JuDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Yoon-Chul KyeDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Cheol Gyun KimDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Young Jin PyungDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Da-Jeong ParkDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Sun-Jong YouAN R&D Center, CJ Feed and Care, Seoul, Republic of Korea.
Hakhyun KaDivision of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
Seung Hyun HanDepartment of Oral Microbiology and Immunology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Cheol-Heui YunDepartment of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host immune status critically influences susceptibility to viral infections; however, the impact of cytokine-driven innate immune differentiation on viral permissiveness remains poorly understood. Here, we investigated whether IL-4-mediated monocyte differentiation modulates porcine reproductive and respiratory syndrome virus (PRRSV) infection. Porcine monocytes were differentiated in the presence of GM-CSF with or without IL-4 to generate monocyte-derived cells (MDCs). Notably, PRRSV replication was significantly higher in MDCs generated without IL-4 compared to those differentiated in the presence of IL-4, which was strongly associated with increased CD163 expression. Consistently, CD163 expression was downregulated in an IL-4-dependent manner. Following PRRSV infection, MDCs differentiated without IL-4 exhibited reduced TNF-

Indexed as

CD163CD8+ T cellinterleukin-4 (IL-4)monocyte derived cell (MDC)porcine reproductive and respiratory syndrome virus (PRRSV)

Identifiers

PMID42326401
PMCPMC13275479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.