ArticleCureus2026
Diagnosis, Management, and Follow-Up of Human Papillomavirus Type 16 (HPV-16) Lesions in the Oral Cavity.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Human papillomavirus (HPV), particularly genotype HPV-16, is strongly associated with oropharyngeal carcinogenesis, although its role in oral cavity lesions remains uncertain. We report the case of a 42-year-old man presenting with leukoplakic lesions affecting the vermilion borders of both lips. Histopathological examination showed non-dysplastic hyperkeratosis, with koilocytosis suggestive of viral infection, and HPV-16 was confirmed by polymerase chain reaction (PCR) analysis. Early recurrence occurred shortly after surgical excision, leading to the implementation of regular clinical surveillance. At the two-year follow-up, no recurrence or malignant transformation was observed, and the lesions remained in complete clinical remission. This case highlights the diagnostic and therapeutic challenges posed by HPV-associated leukoplakic lesions of the oral cavity and emphasizes the importance of careful long-term monitoring.
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