ReviewCureus2026
Environmental Exposure-Induced Epigenetic Modifications and Adverse Pregnancy Outcomes: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal environmental exposures may alter epigenetic regulation, influencing fetal development and pregnancy outcomes. The aim of the study was to systematically review original studies examining associations between environmental exposures, epigenetic modifications, and pregnancy-related disorders. A systematic search of PubMed, ScienceDirect, Cochrane Library, and Google Scholar identified studies evaluating prenatal exposures, epigenetic markers, and clinical outcomes. Study quality was assessed using the Joanna Briggs Institute criteria. Thirty-four studies (2009-2024) were included. Prenatal exposure to air pollutants, heavy metals, endocrine disruptors, and tobacco smoke was associated with global and gene-specific DNA methylation changes, altered miRNA profiles, and histone modifications in placental and cord-blood tissues. These epigenetic alterations were frequently linked to preterm birth, low birth weight, stillbirth, gestational diabetes, and hypertensive disorders of pregnancy. Environmental exposures during pregnancy are consistently associated with measurable epigenetic changes that parallel adverse birth outcomes, supporting their potential role as mechanistic mediators and biomarkers of risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.