ArticleCureus2026
Evaluation of Lipid Profile, High-Sensitivity C-reactive Protein (hs-CRP), and Homocysteine in Premature Acute Myocardial Infarction in a Semi-urban Population: A Case-Control Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The incidence of acute myocardial infarction (AMI) in young adults is progressively increasing, presenting a significant public health challenge. While traditional risk factors are documented, specific roles of atherogenic dyslipidemia and novel inflammatory biomarkers in premature AMI remain under-evaluated in semi-urban populations. Recent evidence suggests that biomarkers such as homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) indicate endothelial dysfunction and vascular inflammation. Hyperhomocysteinemia (HHcy) is associated with oxidative stress and endothelial damage, while elevated hs-CRP levels are linked to plaque instability and a higher risk of cardiovascular events. Aims To evaluate the serum lipid profile, hs-CRP, and Hcy levels in patients with premature AMI in a semi-urban population, and to assess their correlations with glycemic markers. Methods A case-control analytical study was conducted at a tertiary care center in Maharashtra, India. The study enrolled 105 participants divided into three groups: Healthy controls (n=53), old age AMI (≥40 years, n=32), and premature AMI (<40 years, n=20). Fasting venous blood was analyzed for lipid profile, hs-CRP, Hcy, and glycemic markers. Results Patients with premature AMI were predominantly male (85%) with high rates of physical inactivity (90%). This cohort demonstrated profound atherogenic dyslipidemia, characterized by significantly elevated triglycerides (TGs) (238.00 ± 118.75 mg/dL). In premature AMI, TGs showed a significant positive correlation with fasting blood sugar (FBS) (r=0.681, p≤ 0.001), and glycated hemoglobin (HbA1c) (r=0.367, p=0.039). Inflammatory markers were also markedly elevated, with hs-CRP strongly correlating with FBS (r=0.658, p≤0.001). Older patients with AMI showed no such significant correlation between TGs and glycemic markers. Conclusions Premature AMI in this semi-urban population is metabolically distinct, driven by isolated hypertriglyceridemia and chronic inflammation linked to subclinical insulin resistance. A combined assessment of the lipid profile, hs-CRP, and Hcy levels may improve early risk stratification by capturing both atherogenic and inflammatory pathways. Early targeted screening for these biomarkers is crucial for prevention.
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