Evidence map›Paper›PMID 42326070›Full record

ArticleMaterials today. Bio2026

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function.

Shicheng Ye, Zhenguo Wang, Maarten Dirk Delemarre, Nalan Liv, Antoinette van den Dikkenberg, Tina Vermonden, Luc van der Laan, Jos Malda, Bart Spee, Frank G Van Steenbeek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shicheng YeDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.
Zhenguo WangDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.
Maarten Dirk DelemarreDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.
Nalan LivCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Antoinette van den DikkenbergDivision of Pharmaceutics, Department of Pharmaceutical Sciences, Faculty of Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Tina VermondenDivision of Pharmaceutics, Department of Pharmaceutical Sciences, Faculty of Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
Luc van der LaanDepartment of Surgery Erasmus MC-University Medical Center, Dr. Molewaterplein 40, Rotterdam, GD, 3015, Netherlands.
Jos MaldaDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht, CX, 3584, Netherlands.
Bart SpeeDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.
Frank G Van SteenbeekDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.
Kerstin Schneeberger-VerjaalDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Uppsalalaan 8, Utrecht, CT, 3584, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human tissue engineering holds great promise for creating physiological models while facing challenges replicating natural complexity, including cellular and extracellular cues. Current approaches often miss the incorporation of major bioengineering factors (

Indexed as

BioengineeringCo-cultureDynamic suspension cultureHepatic stellate cellHydrogelIntrahepatic cholangiocyte organoidIn vitro models

Identifiers

PMID42326070
PMCPMC13277544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.