ArticleJPRAS open2026
Comparative analysis of hyaluronic acid fillers: Juvéderm Volux versus MaiLi Extreme in microstructural, rheological and mechanical properties.
Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Crosslinked hyaluronic acid fillers (e.g., Juvéderm Volux, MaiLi Extreme [MaiLi-E]) are widely used for deep tissue augmentation, yet systematic comparative analyses are lacking, limiting evidence-based clinical selection. This study provides a systematic comparison across multiple parameters, including the degree of modification, rheological properties, mechanical behavior, and microstructural characteristics, with a preliminary clinical observation of MaiLi-E in chin retrusion correction. Methods: Degree of modification was measured via solution-state ¹H NMR. Elastic modulus (G'), thixotropic index and normal force under compression were measured using a rotational rheometer. Cohesivity was assessed by a drop weight method. Microstructure was examined via scanning electron microscopy (SEM). Chin retrusion patients received a single MaiLi-E injection without touch-ups. The outcomes were evaluated at 3, 6, and 12 months via standardized photographs. Results: MaiLi-E showed lower modification degree (4.86% vs. Juvéderm Volux's 12.26%), lower G' (262 Pa vs. 589 Pa), but higher thixotropic index (5.8 vs. 4.3, +25.9%), normal force (60.89 cN vs. 43.36 cN, +28.8%), and cohesivity (0.2099 g vs. 0.1217 g, +42.0%). SEM revealed MaiLi-E's denser, more uniform microstructure. Clinically, two patients achieved sustained chin retrusion correction at 12 months post-single injection. Conclusions: MaiLi-E exhibited enhanced cohesivity and compression resistance while achieving improved injectability relative to Juvéderm Volux, despite possessing a lower degree of modification. Furthermore, a preliminary clinical observation in human subjects confirmed that MaiLi-E is expected to be applied to chin retrusion correction. These findings indicate that MaiLi-E holds potential in deep tissue augmentation applications, thereby offering practitioners an evidence-based product reference.
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